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Arthur’s Recommended Articles

Dear PMP Pals and Friends,

Listed below is a bibliography which contains current medical and surgical studies of adenocarcinoma of the appendix. These articles appear in medical journals and are directed toward medical professionals. They are written in a specific form and use medical terminology.

To best read these articles, I would suggest that you read the introduction and then the discussion and result sections. You can read through the methodology section but this portion of the article is often difficult to follow.

It is important to note that it is often difficult for even the medical community to grasp all the nuances of a medical paper. I would suggest that you read the paper with an eye toward better understanding the medical analysis that are used to consider treatment modalities. Once you grasp the conclusion of the paper you certainly can re-read the entire article with a greater understanding.

It is sometimes difficult for someone with pmp to read about oneself. However, the emphasis in most of these papers is that further study is necessary to know the best surgical and medical therapy to predict outcomes.  Remember that you cannot extrapolate your own overall survivor rate or tumor-free interval on the basis of these studies. The studies consist of an aggregate of patients and as we know adenocarcinoma of the appendix is a very unpredictable illness. Just because you might fall into a particular category does not mean your outcome will be as stated.

Article one is an excellent review article concerning all varieties of appendiceal cancer. We were given special permission from uptodate, a subscription service for medical professionals. I wish to thank uptodate for allowing us this special access. Please use the link and you will find an excellent starting point to learn about pmp. I wish to thank Mr. Jason Davis of uptodate who worked on getting us this special consideration. 

Articles two and three serve as a platform for the justification of HIPEC therapy for appendiceal carcinoma.

Articles four through ten are a review of the largest series of patients with pmp and address factors in treatment. Also there is a discussion of overall and tumor- free survival.

Articles eleven and twelve discuss the importance of histology in predicting outcomes. This is a very cloudy area since different groups grade tumors differently. These articles will direct you to other discussions of grading pathology and correlation with outcomes.

Articles thirteen through fifteen discuss the importance of tumor markers. These articles are illuminating in discussing the predictive outcomes based solely on tumor marker values.

Articles sixteen through twenty review the genetics of adenocarcinoma and the use of this data to predict outcomes.

The above articles address the most significant issues of appendiceal cancer. However, if you need more information or help in understanding the medical papers I would be more than happy to assist you.

Sincerely, Arthur Rettig

  1. Cancer of the appendix and pseudomyxoma peritonei
  2. HIPEC: The Complexities of Clinical Trials
  3. A new standard of care for the management of peritoneal surface malignancy
  4. Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms
  5. Prospective morbidity and mortality assessment of cytoreductive surgery plus perioperative intraperitoneal chemotherapy to treat peritoneal dissemination of appendiceal mucinous malignancy
  6. Extensive cytoreductive surgery for appendiceal carcinomatosis morbidity, mortality and survival
  7. Recurrence and outcome after complete tumor removal and hyperthermic intraperitoneal chemotherapy in 512 patients with pseudomyxoma peritonei from perforated appendiceal mucinous tumors
  8. Early and long term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
  9. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for peritoneal surface malignancy experience with 1,000 patients
  10. Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy, an emerging treatment option for advanced goblet cell tumors of the appendix
  11. Clinicopathologic and molecular analysis of disseminated appendiceal mucinous neoplasms, identification of factors predicting survival and proposed criteria for a 3 tiered assessment of tumor grade
  12. Importance of histologic subtype in staging of appendiceal tumors
  13. Prognostic value of baseline and serial carcinoembryonic antigen and carbohydrate antigen 19.9 measurements in patients with pseudomyxoma peritonei treated with cytoreduction and Hyperthermic Intraperitoneal Chemotherapy
  14. Inflammatory markers in blood and serum tumor markers predict survival in patients with epithelial appendiceal neoplasms undergoing surgical cytoreduction and intraperitoneal chemotherapy
  15. Significance of serum tumor marker levels in peritoneal carcinomatosis of appendiceal origin
  16. Analysis of loss of heterozygosity for tumor suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix
  17. GNAS is frequently mutated in both low grade and high grade disseminated appendiceal mucinous neoplasms but does not affect survival
  18. Kras mutations and p53 overexpression in pseudomyxoma peritonei, association with phenotype and prognosis
  19. Mucinous and nonmucinous appendiceal adenocarcinomas, different clinicopathological features but similar genetic alterations
  20. Analysis of loss of heterozygosity for tumor suppressor genes can accurately classify and predict the clinical behavior of mucinous tumors arising from the appendix